In My Talking Tom 2, players care for a virtual pet cat named Tom. Core gameplay involves feeding him, putting him to bed, and taking him to the bathroom to maintain his health. Players can also interact by tickling or poking him, prompting humorous repeated speech.

The game includes various mini-games to earn coins, which are used to purchase food and decor. A decorating system allows players to customize Tom's apartment with different furniture and wallpapers. New clothing items can also be unlocked to dress Tom in different styles.

Progression is tied to leveling Tom up by fulfilling his needs, which unlocks new items and locations. The experience is built around daily check-ins and casual interaction with the animated pet.